Overview
SCIENTIFIC SCORE
Questionable
Based on 14 Researches
6.6
USERS' SCORE
Good
Based on 97 Reviews
8.4
Supplement Facts
Serving Size: 1 Veg Capsule
Amount Per Serving
%DV
Sodium (from Sodium Hyaluronate)
10 mg
< 1 %
Hyaluronic Acid (from Sodium Hyaluronate)
100 mg
†
L-Proline (Free-Form)
100 mg
†
Alpha Lipoic Acid
50 mg
†
Grape Seed Extract (Vitis vinifera)(Standardized for Polyphenols)
25 mg
†
Top Medical Research Studies
9
We conducted a study to explore whether intraarticular injections of hyaluronic acid (HA) could effectively treat chronic, nonradicular low back pain as compared to glucocorticoids. Sixty patients participated in a well-structured clinical trial where they received either HA or glucocorticoid injections.
Both treatments resulted in significant pain relief, improved function, and enhanced quality of life. Notably, HA was found to be just as effective as glucocorticoids, and showed even better long-term benefits without any reported side effects.
Both treatments resulted in significant pain relief, improved function, and enhanced quality of life. Notably, HA was found to be just as effective as glucocorticoids, and showed even better long-term benefits without any reported side effects.
Read More
9
We examined how cross-linked hyaluronic acid (cHA) hydrogel can help reduce epidural fibrosis after back surgeries, which is a common cause of ongoing pain. In our study with rat models, we compared groups that received cHA to those that did not.
The results showed that cHA treatment led to lower levels of fibrosis and overall healthier spinal structures. The treated groups had more space around the spinal cord and less thickening of protective membranes. Overall, we found that cHA is promising for managing post-surgical back pain by effectively reducing scar tissue formation.
The results showed that cHA treatment led to lower levels of fibrosis and overall healthier spinal structures. The treated groups had more space around the spinal cord and less thickening of protective membranes. Overall, we found that cHA is promising for managing post-surgical back pain by effectively reducing scar tissue formation.
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2
We assessed the effectiveness of hyaluronic acid (HA) injections for lumbar facet joint arthritis in a small pilot study involving thirteen patients. Each participant underwent a thorough evaluation before treatment, using questionnaires to gauge pain levels and disability. After a precise HA injection, we followed up with evaluations six weeks later.
Unfortunately, our findings indicated that there was no significant improvement in back pain or symptoms following the treatment. This suggests that HA may not be effective for managing lumbar facet joint arthritis at this stage.
Unfortunately, our findings indicated that there was no significant improvement in back pain or symptoms following the treatment. This suggests that HA may not be effective for managing lumbar facet joint arthritis at this stage.
Read More
Most Useful Reviews
9
Improved mobility noted
173 people found this helpful
This supplement has given me tremendous relief for my back pain! After being recommended for degenerative disc disease, it made me much more mobile within just a week. It is easy to take, and since it’s a long chain of disaccharides, it aids in moisture retention in connective tissues. I highly recommend it as I've experienced remarkable improvements in my chronic back pain.
Read More
10
Back pain relief
82 people found this helpful
I had thinned intervertebral discs and displaced vertebrae. After three months on glucosamine with MSM and collagen, my pain has gone. After suffering chronic pain for over five years, I’m finally happy!
Read More
7.5
Significant pain reduction
33 people found this helpful
I suffer from osteoarthritis in both my hands and knees, with worsening pain upon waking. This product has provided relief when nothing else worked. I’ve tried various pain medications, but didn't want to rely on them daily. After taking one capsule each evening for six weeks, I’ve noticed a considerable reduction in pain and stiffness upon waking. Some mornings, I don’t even notice the pain anymore, and I have shared this with others who have experienced similar results. It's an economical option worth trying for osteoarthritis or degenerative joint issues!
Read More
Medical Researches
SCIENTIFIC SCORE
Questionable
Based on 14 Researches
6.6
- All Researches
9
We examined how cross-linked hyaluronic acid (cHA) hydrogel can help reduce epidural fibrosis after back surgeries, which is a common cause of ongoing pain. In our study with rat models, we compared groups that received cHA to those that did not.
The results showed that cHA treatment led to lower levels of fibrosis and overall healthier spinal structures. The treated groups had more space around the spinal cord and less thickening of protective membranes. Overall, we found that cHA is promising for managing post-surgical back pain by effectively reducing scar tissue formation.
The results showed that cHA treatment led to lower levels of fibrosis and overall healthier spinal structures. The treated groups had more space around the spinal cord and less thickening of protective membranes. Overall, we found that cHA is promising for managing post-surgical back pain by effectively reducing scar tissue formation.
Read More
9
We conducted a study to explore whether intraarticular injections of hyaluronic acid (HA) could effectively treat chronic, nonradicular low back pain as compared to glucocorticoids. Sixty patients participated in a well-structured clinical trial where they received either HA or glucocorticoid injections.
Both treatments resulted in significant pain relief, improved function, and enhanced quality of life. Notably, HA was found to be just as effective as glucocorticoids, and showed even better long-term benefits without any reported side effects.
Both treatments resulted in significant pain relief, improved function, and enhanced quality of life. Notably, HA was found to be just as effective as glucocorticoids, and showed even better long-term benefits without any reported side effects.
Read More
8
We examined the effects of hyaluronic acid in healing back pain linked to disc degeneration. In our study, New Zealand white rabbits undergoing a partial nucleotomy received either PGA/HA implants or bioactivated fibrin, while controls underwent the procedure without any treatment.
Our results indicated that the use of PGA/HA implants led to more effective tissue repair, evidenced by a significant increase in type II collagen content, compared to the untreated controls. However, there was no change in the water content of the discs over the six-month period, highlighting that while tissue repair may improve, it may not directly enhance disc hydration or overall disc function.
Our results indicated that the use of PGA/HA implants led to more effective tissue repair, evidenced by a significant increase in type II collagen content, compared to the untreated controls. However, there was no change in the water content of the discs over the six-month period, highlighting that while tissue repair may improve, it may not directly enhance disc hydration or overall disc function.
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8
Sacroiliac joint pain treatment review
We explored the complex nature of chronic pain in the sacroiliac joint, which has long sparked debate due to its anatomical position. This makes accurate diagnosis challenging, often requiring advanced techniques like guided injections.
While there are various treatment options available for sacroiliac joint syndrome, no single method has proven to be ideal. However, using hyaluronic acid through intra-articular viscosupplementation has shown promise in delivering long-lasting pain relief, promoting healthy joint function, and enhancing synovial fluid properties.
While there are various treatment options available for sacroiliac joint syndrome, no single method has proven to be ideal. However, using hyaluronic acid through intra-articular viscosupplementation has shown promise in delivering long-lasting pain relief, promoting healthy joint function, and enhancing synovial fluid properties.
Read More
7
Safety and feasibility confirmed
We explored the safety and feasibility of using hyaluronic acid alongside specially prepared stem cells to treat chronic low back pain. In a small study involving eight patients, everyone received a single injection while being monitored over six months.
Thankfully, there were no reported complications, and six out of eight participants showed meaningful improvements in pain and disability scores. While radiological changes were noted in four patients, the overall findings highlight the potential of this treatment as a safe option for chronic disc-related pain. However, further research is needed to confirm its effectiveness.
Thankfully, there were no reported complications, and six out of eight participants showed meaningful improvements in pain and disability scores. While radiological changes were noted in four patients, the overall findings highlight the potential of this treatment as a safe option for chronic disc-related pain. However, further research is needed to confirm its effectiveness.
Read More
User Reviews
USERS' SCORE
Good
Based on 97 Reviews
8.4
- All Reviews
- Positive Reviews
- Negative Reviews
9
Improved mobility noted
173 people found this helpful
This supplement has given me tremendous relief for my back pain! After being recommended for degenerative disc disease, it made me much more mobile within just a week. It is easy to take, and since it’s a long chain of disaccharides, it aids in moisture retention in connective tissues. I highly recommend it as I've experienced remarkable improvements in my chronic back pain.
Read More
10
Back pain relief
82 people found this helpful
I had thinned intervertebral discs and displaced vertebrae. After three months on glucosamine with MSM and collagen, my pain has gone. After suffering chronic pain for over five years, I’m finally happy!
Read More
7.5
Significant pain reduction
33 people found this helpful
I suffer from osteoarthritis in both my hands and knees, with worsening pain upon waking. This product has provided relief when nothing else worked. I’ve tried various pain medications, but didn't want to rely on them daily. After taking one capsule each evening for six weeks, I’ve noticed a considerable reduction in pain and stiffness upon waking. Some mornings, I don’t even notice the pain anymore, and I have shared this with others who have experienced similar results. It's an economical option worth trying for osteoarthritis or degenerative joint issues!
Read More
9
Reduced back pain
30 people found this helpful
Now Foods' Hyaluronic Acid is the best for joints and skin. My knees, shoulders, and elbows feel great, and my form is much improved during workouts. Pain and irritation have nearly vanished.
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10
Back pain improvement
28 people found this helpful
This stuff seems to work! My knee, which has troubled me for years, stopped hurting after taking Now Foods Hyaluronic Acid. It’s been a remarkable improvement for both me and my wife's arthritis.
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Frequently Asked Questions
9
Mother's back pain gone
16 people found this helpful
My mother’s lifelong back pain has disappeared in just two weeks after taking Hyaluronic Acid and collagen. She now moves comfortably and easily, which brings me great joy.
9
Joint pain relief
4 people found this helpful
The quality of this product is superb. After only a couple of applications, my mother-in-law felt relief from her back pain caused by lumbar issues. I noticed my joints felt much stronger. I'm very satisfied with the effects, particularly in reducing back pain.
9
Reduced back pain
3 people found this helpful
I bought collagen and a joint supplement for my mother's patella. A month later, her back pain was gone, and her skin noticeably improved. Her friends commented on her smooth, radiant skin. I purchased it for myself and shared it with her friends too.
10
Back pain relief
82 people found this helpful
I had thinned intervertebral discs and displaced vertebrae. After three months on glucosamine with MSM and collagen, my pain has gone. After suffering chronic pain for over five years, I’m finally happy!
9
Back pain alleviated
2 people found this helpful
After developing significant knee and hip pain from working long hours, I introduced this supplement to my regimen. Within six weeks, my back pain had improved remarkably. Now, my joints feel youthful.
10
Pain-free hip
16 people found this helpful
I've experienced severe hip pain that disrupted my sleep but after starting Now Foods' Hyaluronic Acid, I have forgotten the pain within days.
9
Miracle for back pain
7 people found this helpful
After sustaining severe knee arthritis from an accident and finding little relief from cortisone injections, I tried NOW Hyaluronic Acid. Within a week, I felt relief, and even older pain in a thumb vanished. Now, I can't live without it!
9
Knee discomfort vanished
7 people found this helpful
After using this product for a month alongside glucosamine/chondroitin, my knee pain when moving noticeably diminished. I was able to climb stairs easily after almost a year of struggle. I didn’t expect such quick results.
9
Hip pain gone
5 people found this helpful
I've taken collagen peptides and L-proline for ages but found that using this product has significantly improved my skin's moisture. In conjunction with other supplements, it eliminated persistent hip pain.
9
Improved wellbeing
16 people found this helpful
I take a complex aimed at boosting collagen production and rejuvenation. The results, including reduced fatigue and better skin, have been excellent. My overall energy has increased, and my discomfort has diminished.
9
Improved back pain
4 people found this helpful
Since taking two of these daily, my surgically repaired knee and back pain have considerably improved. They work well with glucosamine and MSM. Highly recommended for anyone experiencing joint and back issues.
9
No joint pain
3 people found this helpful
I've been taking this for 12 years. At 85 years old, I've completely overcome my back pain. I started with two capsules daily, switching to one after two weeks. I prefer the NOW brand, but others work too.
9
Fingers pain relief
5 people found this helpful
I’ve been taking one tablet daily for three weeks for chronic arthritis in my fingers and knees. After trying various anti-inflammatories with no success, I can now enjoy relief from pain, especially in my fingers and hands.
7
We explored the impact of combining therapeutic exercise with dietary supplements, including hyaluronic acid, on chronic low back pain. In this study, 60 patients were split into two groups—one receiving only exercise and the other incorporating these supplements.
The results showed that those taking supplements, alongside their exercise regimen, experienced more significant relief from pain and improved quality of life compared to those who exercised alone. Thus, using hyaluronic acid with rehabilitation exercises could be a beneficial approach for managing chronic low back pain.
The results showed that those taking supplements, alongside their exercise regimen, experienced more significant relief from pain and improved quality of life compared to those who exercised alone. Thus, using hyaluronic acid with rehabilitation exercises could be a beneficial approach for managing chronic low back pain.
4
We examined the effectiveness of hyaluronic acid in managing chronic low back pain originating from facet joint osteoarthritis. Our systematic review analyzed various injectable treatments, focusing on outcomes from randomized clinical trials.
While steroids and local anesthetics showed promising results, hyaluronic acid did not demonstrate significant benefits, unlike other treatments we explored.
Overall, injections for this type of back pain are encouraging, especially with medial branch blocks, but the role of hyaluronic acid remains unclear.
While steroids and local anesthetics showed promising results, hyaluronic acid did not demonstrate significant benefits, unlike other treatments we explored.
Overall, injections for this type of back pain are encouraging, especially with medial branch blocks, but the role of hyaluronic acid remains unclear.
7
Hyaluronic acid shows limited benefit
We evaluated the safety and effectiveness of injecting mesenchymal precursor cells and hyaluronic acid (HA) in individuals suffering from chronic low back pain linked to degenerative disc disease. In a multicenter study involving 100 participants, we measured their pain and disability levels using visual scales and questionnaires at various intervals over three years.
Unfortunately, our findings did not show significant improvements in back pain relief attributable to HA. While there were some safety and effectiveness indicators for the treatment, the overall benefits of HA weren't substantial enough to draw strong conclusions.
Unfortunately, our findings did not show significant improvements in back pain relief attributable to HA. While there were some safety and effectiveness indicators for the treatment, the overall benefits of HA weren't substantial enough to draw strong conclusions.
5
Hyaluronic acid shows limited benefits
We undertook a double-blind, randomized controlled trial involving 30 participants to compare hyaluronic acid (HA) with triamcinolone for treating chronic low back pain linked to specific joint issues.
After evaluating pain and disability scores over six months, we observed that both treatments yielded similar results, with both groups reporting short-term functional improvements. However, HA injection resulted in significant long-term functional enhancements and some short-term pain relief.
In contrast, triamcinolone provided only limited short-term benefits, indicating that while HA shows promise, it might not be a clear winner over triamcinolone in overall pain relief.
After evaluating pain and disability scores over six months, we observed that both treatments yielded similar results, with both groups reporting short-term functional improvements. However, HA injection resulted in significant long-term functional enhancements and some short-term pain relief.
In contrast, triamcinolone provided only limited short-term benefits, indicating that while HA shows promise, it might not be a clear winner over triamcinolone in overall pain relief.
References
- Lee DH, Park KS, Shin HE, Kim SB, Choi H, et al. Safety and Feasibility of Intradiscal Administration of Matrilin-3-Primed Adipose-Derived Mesenchymal Stromal Cell Spheroids for Chronic Discogenic Low Back Pain: Phase 1 Clinical Trial. Int J Mol Sci. 2023;24. doi:10.3390/ijms242316827
- Goode AP, Cleveland RJ, Kraus VB, Taylor KA, George SZ, et al. Biomarkers and longitudinal changes in lumbar spine degeneration and low back pain: the Johnston County Osteoarthritis Project. Osteoarthritis Cartilage. 2023;31:809. doi:10.1016/j.joca.2023.02.005
- Shavlovskaya OA. [Complex effects of physical exertion with dietary supplements Cartilox in pain syndrome effectiveness and safety evaluation]. Vopr Kurortol Fizioter Lech Fiz Kult. 2022;99:20. doi:10.17116/kurort20229904120
- Baroncini A, Maffulli N, Eschweiler J, Knobe M, Tingart M, et al. Management of facet joints osteoarthritis associated with chronic low back pain: A systematic review. Surgeon. 2021;19:e512. doi:10.1016/j.surge.2020.12.004
- Farì G, Santagati D, Pignatelli G, Scacco V, Renna D, et al. Collagen Peptides, in Association with Vitamin C, Sodium Hyaluronate, Manganese and Copper, as Part of the Rehabilitation Project in the Treatment of Chronic Low Back Pain. Endocr Metab Immune Disord Drug Targets. 2022;22:108. doi:10.2174/1871530321666210210153619
- Amirdelfan K, Bae H, McJunkin T, DePalma M, Kim K, et al. Allogeneic mesenchymal precursor cells treatment for chronic low back pain associated with degenerative disc disease: a prospective randomized, placebo-controlled 36-month study of safety and efficacy. Spine J. 2021;21:212. doi:10.1016/j.spinee.2020.10.004
- Annaswamy TM, Armstead C, Carlson L, Elkins NJ, Kocak D, et al. Intra-articular Triamcinolone Versus Hyaluronate Injections for Low Back Pain With Symptoms Suggestive of Lumbar Zygapophyseal Joint Arthropathy: A Pragmatic, Double-Blind Randomized Controlled Trial. Am J Phys Med Rehabil. 2018;97:278. doi:10.1097/PHM.0000000000000879
- Kumar H, Ha DH, Lee EJ, Park JH, Shim JH, et al. Safety and tolerability of intradiscal implantation of combined autologous adipose-derived mesenchymal stem cells and hyaluronic acid in patients with chronic discogenic low back pain: 1-year follow-up of a phase I study. Stem Cell Res Ther. 2017;8:262. doi:10.1186/s13287-017-0710-3
- Wu CY, Huang YH, Lee JS, Tai TW, Wu PT, et al. Efficacy of topical cross-linked hyaluronic acid hydrogel in preventing post laminectomy/laminotomy fibrosis in a rat model. J Orthop Res. 2016;34:299. doi:10.1002/jor.23001
- Endres M, Zenclussen ML, Casalis PA, Freymann U, Gil Garcia S, et al. Augmentation and repair tissue formation of the nucleus pulposus after partial nucleotomy in a rabbit model. Tissue Cell. 2014;46:505. doi:10.1016/j.tice.2014.09.003
- Cleary M, Keating C, Poynton AR. Viscosupplementation in lumbar facet joint arthropathy: a pilot study. J Spinal Disord Tech. 2008;21:29. doi:10.1097/BSD.0b013e318057720c
- Fuchs S, Erbe T, Fischer HL, Tibesku CO. Intraarticular hyaluronic acid versus glucocorticoid injections for nonradicular pain in the lumbar spine. J Vasc Interv Radiol. 2005;16:1493.
- Calvillo O, Skaribas I, Turnipseed J. Anatomy and pathophysiology of the sacroiliac joint. Curr Rev Pain. 2000;4:356.
- Srejic U, Calvillo O, Kabakibou K. Viscosupplementation: a new concept in the treatment of sacroiliac joint syndrome: a preliminary report of four cases. Reg Anesth Pain Med. 1999;24:84.
