Last update
3/22/2026
Reviewed By
Reviewed By
Overview
SCIENTIFIC SCORE
Questionable
Based on 14 Researches
6.6
USERS' SCORE
Good
Based on 19 Reviews
8.4
Supplement Facts
Serving Size: 1 Veg Capsule
Amount Per Serving
%DV
Sodium (from Sodium Hyaluronate)
10 mg
< 1 %
Hyaluronic Acid (from Sodium Hyaluronate)
100 mg
†
L-Proline (Free-Form)
100 mg
†
Alpha Lipoic Acid
50 mg
†
Grape Seed Extract (Vitis vinifera)(Standardized for Polyphenols)
25 mg
†
Top Medical Research Studies
9
We conducted a study to explore whether intraarticular injections of hyaluronic acid (HA) could effectively treat chronic, nonradicular low back pain as compared to glucocorticoids. Sixty patients participated in a well-structured clinical trial where they received either HA or glucocorticoid injections.
Both treatments resulted in significant pain relief, improved function, and enhanced quality of life. Notably, HA was found to be just as effective as glucocorticoids, and showed even better long-term benefits without any reported side effects.
Both treatments resulted in significant pain relief, improved function, and enhanced quality of life. Notably, HA was found to be just as effective as glucocorticoids, and showed even better long-term benefits without any reported side effects.
Read More
9
We examined how cross-linked hyaluronic acid (cHA) hydrogel can help reduce epidural fibrosis after back surgeries, which is a common cause of ongoing pain. In our study with rat models, we compared groups that received cHA to those that did not.
The results showed that cHA treatment led to lower levels of fibrosis and overall healthier spinal structures. The treated groups had more space around the spinal cord and less thickening of protective membranes. Overall, we found that cHA is promising for managing post-surgical back pain by effectively reducing scar tissue formation.
The results showed that cHA treatment led to lower levels of fibrosis and overall healthier spinal structures. The treated groups had more space around the spinal cord and less thickening of protective membranes. Overall, we found that cHA is promising for managing post-surgical back pain by effectively reducing scar tissue formation.
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2
We assessed the effectiveness of hyaluronic acid (HA) injections for lumbar facet joint arthritis in a small pilot study involving thirteen patients. Each participant underwent a thorough evaluation before treatment, using questionnaires to gauge pain levels and disability. After a precise HA injection, we followed up with evaluations six weeks later.
Unfortunately, our findings indicated that there was no significant improvement in back pain or symptoms following the treatment. This suggests that HA may not be effective for managing lumbar facet joint arthritis at this stage.
Unfortunately, our findings indicated that there was no significant improvement in back pain or symptoms following the treatment. This suggests that HA may not be effective for managing lumbar facet joint arthritis at this stage.
Read More
Most Useful Reviews
9
Improved mobility noted
173 people found this helpful
This supplement has given me tremendous relief for my back pain! After being recommended for degenerative disc disease, it made me much more mobile within just a week. It is easy to take, and since it’s a long chain of disaccharides, it aids in moisture retention in connective tissues. I highly recommend it as I've experienced remarkable improvements in my chronic back pain.
Read More
7.5
Significant pain reduction
33 people found this helpful
I suffer from osteoarthritis in both my hands and knees, with worsening pain upon waking. This product has provided relief when nothing else worked. I’ve tried various pain medications, but didn't want to rely on them daily. After taking one capsule each evening for six weeks, I’ve noticed a considerable reduction in pain and stiffness upon waking. Some mornings, I don’t even notice the pain anymore, and I have shared this with others who have experienced similar results. It's an economical option worth trying for osteoarthritis or degenerative joint issues!
Read More
9
No more pain
28 people found this helpful
Remarkably, I rarely write reviews. I was set to have knee surgery in January 2019 and had been taking 15mg of Mobic daily for chronic pain for five years. Since I started taking NOW Hyaluronic Acid, 100mg, in December, I realised around Christmas time that I had 95% less knee pain and cancelled my surgery. I no longer need Mobic. Give this a go for 3 to 4 weeks.
Read More
Medical Researches
SCIENTIFIC SCORE
Questionable
Based on 14 Researches
6.6
- All Researches
9
We examined how cross-linked hyaluronic acid (cHA) hydrogel can help reduce epidural fibrosis after back surgeries, which is a common cause of ongoing pain. In our study with rat models, we compared groups that received cHA to those that did not.
The results showed that cHA treatment led to lower levels of fibrosis and overall healthier spinal structures. The treated groups had more space around the spinal cord and less thickening of protective membranes. Overall, we found that cHA is promising for managing post-surgical back pain by effectively reducing scar tissue formation.
The results showed that cHA treatment led to lower levels of fibrosis and overall healthier spinal structures. The treated groups had more space around the spinal cord and less thickening of protective membranes. Overall, we found that cHA is promising for managing post-surgical back pain by effectively reducing scar tissue formation.
Read More
9
We conducted a study to explore whether intraarticular injections of hyaluronic acid (HA) could effectively treat chronic, nonradicular low back pain as compared to glucocorticoids. Sixty patients participated in a well-structured clinical trial where they received either HA or glucocorticoid injections.
Both treatments resulted in significant pain relief, improved function, and enhanced quality of life. Notably, HA was found to be just as effective as glucocorticoids, and showed even better long-term benefits without any reported side effects.
Both treatments resulted in significant pain relief, improved function, and enhanced quality of life. Notably, HA was found to be just as effective as glucocorticoids, and showed even better long-term benefits without any reported side effects.
Read More
8
We examined the effects of hyaluronic acid in healing back pain linked to disc degeneration. In our study, New Zealand white rabbits undergoing a partial nucleotomy received either PGA/HA implants or bioactivated fibrin, while controls underwent the procedure without any treatment.
Our results indicated that the use of PGA/HA implants led to more effective tissue repair, evidenced by a significant increase in type II collagen content, compared to the untreated controls. However, there was no change in the water content of the discs over the six-month period, highlighting that while tissue repair may improve, it may not directly enhance disc hydration or overall disc function.
Our results indicated that the use of PGA/HA implants led to more effective tissue repair, evidenced by a significant increase in type II collagen content, compared to the untreated controls. However, there was no change in the water content of the discs over the six-month period, highlighting that while tissue repair may improve, it may not directly enhance disc hydration or overall disc function.
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8
Sacroiliac joint pain treatment review
We explored the complex nature of chronic pain in the sacroiliac joint, which has long sparked debate due to its anatomical position. This makes accurate diagnosis challenging, often requiring advanced techniques like guided injections.
While there are various treatment options available for sacroiliac joint syndrome, no single method has proven to be ideal. However, using hyaluronic acid through intra-articular viscosupplementation has shown promise in delivering long-lasting pain relief, promoting healthy joint function, and enhancing synovial fluid properties.
While there are various treatment options available for sacroiliac joint syndrome, no single method has proven to be ideal. However, using hyaluronic acid through intra-articular viscosupplementation has shown promise in delivering long-lasting pain relief, promoting healthy joint function, and enhancing synovial fluid properties.
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7
Safety and feasibility confirmed
We explored the safety and feasibility of using hyaluronic acid alongside specially prepared stem cells to treat chronic low back pain. In a small study involving eight patients, everyone received a single injection while being monitored over six months.
Thankfully, there were no reported complications, and six out of eight participants showed meaningful improvements in pain and disability scores. While radiological changes were noted in four patients, the overall findings highlight the potential of this treatment as a safe option for chronic disc-related pain. However, further research is needed to confirm its effectiveness.
Thankfully, there were no reported complications, and six out of eight participants showed meaningful improvements in pain and disability scores. While radiological changes were noted in four patients, the overall findings highlight the potential of this treatment as a safe option for chronic disc-related pain. However, further research is needed to confirm its effectiveness.
Read More
User Reviews
USERS' SCORE
Good
Based on 19 Reviews
8.4
- All Reviews
- Positive Reviews
- Negative Reviews
9
Improved mobility noted
173 people found this helpful
This supplement has given me tremendous relief for my back pain! After being recommended for degenerative disc disease, it made me much more mobile within just a week. It is easy to take, and since it’s a long chain of disaccharides, it aids in moisture retention in connective tissues. I highly recommend it as I've experienced remarkable improvements in my chronic back pain.
Read More
7.5
Significant pain reduction
33 people found this helpful
I suffer from osteoarthritis in both my hands and knees, with worsening pain upon waking. This product has provided relief when nothing else worked. I’ve tried various pain medications, but didn't want to rely on them daily. After taking one capsule each evening for six weeks, I’ve noticed a considerable reduction in pain and stiffness upon waking. Some mornings, I don’t even notice the pain anymore, and I have shared this with others who have experienced similar results. It's an economical option worth trying for osteoarthritis or degenerative joint issues!
Read More
9
No more pain
28 people found this helpful
Remarkably, I rarely write reviews. I was set to have knee surgery in January 2019 and had been taking 15mg of Mobic daily for chronic pain for five years. Since I started taking NOW Hyaluronic Acid, 100mg, in December, I realised around Christmas time that I had 95% less knee pain and cancelled my surgery. I no longer need Mobic. Give this a go for 3 to 4 weeks.
Read More
9
Pain-free running
18 people found this helpful
It's true what they say! I used to run and do hill sprints but my knees limited me. Since taking this product, I've been able to run every other day without any joint pain. Initially, I took double the recommended dose, but the benefits were evident within two days. I reduced the intake to one capsule morning and night after a month with no drop in effectiveness. It’s definitely a great product.
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7.5
Knee pain improvement
8 people found this helpful
After being diagnosed with pre-arthritis, I struggled with pain and swelling in my knees. A family member recommended hyaluronic acid, and after 4-6 weeks, I experienced less pain and increased joint mobility. I can now bend down without support, and my knees no longer ache at night. I’ve been taking this supplement for nine months and don’t plan to run out as it has also improved my skin condition.
Read More
Frequently Asked Questions
7
We explored the impact of combining therapeutic exercise with dietary supplements, including hyaluronic acid, on chronic low back pain. In this study, 60 patients were split into two groups—one receiving only exercise and the other incorporating these supplements.
The results showed that those taking supplements, alongside their exercise regimen, experienced more significant relief from pain and improved quality of life compared to those who exercised alone. Thus, using hyaluronic acid with rehabilitation exercises could be a beneficial approach for managing chronic low back pain.
The results showed that those taking supplements, alongside their exercise regimen, experienced more significant relief from pain and improved quality of life compared to those who exercised alone. Thus, using hyaluronic acid with rehabilitation exercises could be a beneficial approach for managing chronic low back pain.
4
We examined the effectiveness of hyaluronic acid in managing chronic low back pain originating from facet joint osteoarthritis. Our systematic review analyzed various injectable treatments, focusing on outcomes from randomized clinical trials.
While steroids and local anesthetics showed promising results, hyaluronic acid did not demonstrate significant benefits, unlike other treatments we explored.
Overall, injections for this type of back pain are encouraging, especially with medial branch blocks, but the role of hyaluronic acid remains unclear.
While steroids and local anesthetics showed promising results, hyaluronic acid did not demonstrate significant benefits, unlike other treatments we explored.
Overall, injections for this type of back pain are encouraging, especially with medial branch blocks, but the role of hyaluronic acid remains unclear.
7
Hyaluronic acid shows limited benefit
We evaluated the safety and effectiveness of injecting mesenchymal precursor cells and hyaluronic acid (HA) in individuals suffering from chronic low back pain linked to degenerative disc disease. In a multicenter study involving 100 participants, we measured their pain and disability levels using visual scales and questionnaires at various intervals over three years.
Unfortunately, our findings did not show significant improvements in back pain relief attributable to HA. While there were some safety and effectiveness indicators for the treatment, the overall benefits of HA weren't substantial enough to draw strong conclusions.
Unfortunately, our findings did not show significant improvements in back pain relief attributable to HA. While there were some safety and effectiveness indicators for the treatment, the overall benefits of HA weren't substantial enough to draw strong conclusions.
5
Hyaluronic acid shows limited benefits
We undertook a double-blind, randomized controlled trial involving 30 participants to compare hyaluronic acid (HA) with triamcinolone for treating chronic low back pain linked to specific joint issues.
After evaluating pain and disability scores over six months, we observed that both treatments yielded similar results, with both groups reporting short-term functional improvements. However, HA injection resulted in significant long-term functional enhancements and some short-term pain relief.
In contrast, triamcinolone provided only limited short-term benefits, indicating that while HA shows promise, it might not be a clear winner over triamcinolone in overall pain relief.
After evaluating pain and disability scores over six months, we observed that both treatments yielded similar results, with both groups reporting short-term functional improvements. However, HA injection resulted in significant long-term functional enhancements and some short-term pain relief.
In contrast, triamcinolone provided only limited short-term benefits, indicating that while HA shows promise, it might not be a clear winner over triamcinolone in overall pain relief.
References
- Lee DH, Park KS, Shin HE, Kim SB, Choi H, et al. Safety and Feasibility of Intradiscal Administration of Matrilin-3-Primed Adipose-Derived Mesenchymal Stromal Cell Spheroids for Chronic Discogenic Low Back Pain: Phase 1 Clinical Trial. Int J Mol Sci. 2023;24. 10.3390/ijms242316827
- Goode AP, Cleveland RJ, Kraus VB, Taylor KA, George SZ, et al. Biomarkers and longitudinal changes in lumbar spine degeneration and low back pain: the Johnston County Osteoarthritis Project. Osteoarthritis Cartilage. 2023;31:809. 10.1016/j.joca.2023.02.005
- Shavlovskaya OA. [Complex effects of physical exertion with dietary supplements Cartilox in pain syndrome effectiveness and safety evaluation]. Vopr Kurortol Fizioter Lech Fiz Kult. 2022;99:20. 10.17116/kurort20229904120
- Baroncini A, Maffulli N, Eschweiler J, Knobe M, Tingart M, et al. Management of facet joints osteoarthritis associated with chronic low back pain: A systematic review. Surgeon. 2021;19:e512. 10.1016/j.surge.2020.12.004
- Farì G, Santagati D, Pignatelli G, Scacco V, Renna D, et al. Collagen Peptides, in Association with Vitamin C, Sodium Hyaluronate, Manganese and Copper, as Part of the Rehabilitation Project in the Treatment of Chronic Low Back Pain. Endocr Metab Immune Disord Drug Targets. 2022;22:108. 10.2174/1871530321666210210153619
- Amirdelfan K, Bae H, McJunkin T, DePalma M, Kim K, et al. Allogeneic mesenchymal precursor cells treatment for chronic low back pain associated with degenerative disc disease: a prospective randomized, placebo-controlled 36-month study of safety and efficacy. Spine J. 2021;21:212. 10.1016/j.spinee.2020.10.004
- Annaswamy TM, Armstead C, Carlson L, Elkins NJ, Kocak D, et al. Intra-articular Triamcinolone Versus Hyaluronate Injections for Low Back Pain With Symptoms Suggestive of Lumbar Zygapophyseal Joint Arthropathy: A Pragmatic, Double-Blind Randomized Controlled Trial. Am J Phys Med Rehabil. 2018;97:278. 10.1097/PHM.0000000000000879
- Kumar H, Ha DH, Lee EJ, Park JH, Shim JH, et al. Safety and tolerability of intradiscal implantation of combined autologous adipose-derived mesenchymal stem cells and hyaluronic acid in patients with chronic discogenic low back pain: 1-year follow-up of a phase I study. Stem Cell Res Ther. 2017;8:262. 10.1186/s13287-017-0710-3
- Wu CY, Huang YH, Lee JS, Tai TW, Wu PT, et al. Efficacy of topical cross-linked hyaluronic acid hydrogel in preventing post laminectomy/laminotomy fibrosis in a rat model. J Orthop Res. 2016;34:299. 10.1002/jor.23001
- Endres M, Zenclussen ML, Casalis PA, Freymann U, Gil Garcia S, et al. Augmentation and repair tissue formation of the nucleus pulposus after partial nucleotomy in a rabbit model. Tissue Cell. 2014;46:505. 10.1016/j.tice.2014.09.003
- Cleary M, Keating C, Poynton AR. Viscosupplementation in lumbar facet joint arthropathy: a pilot study. J Spinal Disord Tech. 2008;21:29. 10.1097/BSD.0b013e318057720c
- Fuchs S, Erbe T, Fischer HL, Tibesku CO. Intraarticular hyaluronic acid versus glucocorticoid injections for nonradicular pain in the lumbar spine. J Vasc Interv Radiol. 2005;16:1493. PubMed
- Calvillo O, Skaribas I, Turnipseed J. Anatomy and pathophysiology of the sacroiliac joint. Curr Rev Pain. 2000;4:356. PubMed
- Srejic U, Calvillo O, Kabakibou K. Viscosupplementation: a new concept in the treatment of sacroiliac joint syndrome: a preliminary report of four cases. Reg Anesth Pain Med. 1999;24:84. PubMed
Data last updated:
